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Most often used in construction, PVC is a plastic composed of three elements: carbon, hydrogen and chlorine. In 1974 vinyl chloride (VC), a gas used in the plastics industry, was shown to be a human carcinogen, inducing a very rare type of tumor, angiosarcoma of the liver. Vinyl chloride ≥99.5%; CAS Number: 75-01-4; EC Number: 200-831-0; Synonym: Chloroethylene; Linear Formula: C2H3Cl; find Sigma-Aldrich-387622 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Workers at facilities where vinyl chloride is produced or used may be exposed primarily through inhalation. Vinyl chloride is a known human carcinogen (cancer-causing agent). It does not occur naturally and must be produced industrially for its commercial uses. Latency period between exposure and vinyl chloride related cancers varies strongly depending on the different types of cancer. The same type of tumor was induced in rodents exposed to VC thus providing an excellent model for mechanistic studies. Some strains of obligate organohalide respiring Dehalococcoides mccartyi can synthesize the VC reductase that catalyzes the dechlorination of VC to ethene. Healthy Child Healthy World describes PVC as the most toxic plastic , and vinyl chloride, the chemical used to make PVC, has been described as a known carcinogen by the World Health Organization's International Agency for Research on Cancer. Where risks occur The main route of occupational exposure to vinyl chloride is by inhalation, which occurs primarily in vinyl chloride/PVC plants and in PVC-processing plants (including packaging, storage and handling of vinyl chloride). of vinyl chloride, i.e., early exposures are associated with higher liver cancer incidence than similar or much longer exposures that occur after maturity. Make sure the right personal protective equipment and clothing is used, like safety goggles, chemical resistant clothing and gloves (chemical resistant or insulated) and respirators. Primary Cause of Human carcinogen -- Vinyl Chloride . Please Note: The main sources of information for this fact sheet are the Agency for Toxic Substances and Disease Vinyl Chloride Carcinogenic Potency Dose Response Data Animal Colony Fisher Exact Probability Test These keywords were added by machine and not by the authors. Chronic exposure can cause permanent liver injury and liver cancer, neurologic or behavioral symptoms and changes to the skin and bones of the hand. Gene-environmentinteractions between DNA repair polymorphisms and exposure to the carcinogen vinyl chloride.Biomarkers 2009;14:148-55. Vinyl chloride is classified as a “known human carcinogen” by the NTP and the USEPA, and as a Group 1 human carcinogen by the IARC, with known target sites including the liver, lung, and connective tissues [19,109,112]. It can also irritate the eyes, skin, mucous membranes and respiratory tract. If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. If a water supply is contaminated, vinyl chloride can enter household air when the water is used for showering, cooking, or laundry. substance or exposure is only on one agency’s list, this it does not necessarily mean there is a controversy, as one agency may not have evaluated Triangle Park, NC: National Institute of Environmental Health and Safety, 2016. At low exposure levels, the body is able to metabolize vinyl chloride and excrete it in urine. Employers shall ensure that each employee has access to labels on containers of vinyl chloride and to safety data sheets, and is trained in accordance with the requirements of HCS and paragraph (j) of this section. The primary target organ for vinyl chloride exposure is the liver (1, 2). Long term overexposure to Vinyl Chloride in humans and laboratory animals has been known to cause angiosarcoma of the liver. Vinyl chloride exposure is associated with an increased risk of a rare form of liver cancer (hepatic angiosarcoma), as well as brain and lung cancers, lymphoma, and leukemia. National Toxicology Program. Vinyl chloride is a highly dangerous chemical used to make numerous plastic materials. Best solution is to control exposure by elimination or substitution, for example replacing vinyl chloride by another non-carcinogenic substance, install ventilation systems or secure the processes. Public Health Statement: Vinyl Chloride. inhalation, ingestion, skin contact), duration and level of exposure. Human carcinogen -- Vinyl Chloride: Vinyl Chloride is deemed to be carcinogenic to humans. The U.S. Occupational Safety & Health Administration provides information about exposure limits to vinyl chloride. Here, we review … or the Agency’s) Guidelines for Carcinogen Risk Assessment, published in 51 FR 33992, September 24, 1986 (U.S. EPA, 1986a) and the 1999 interim final guidelines (U.S. EPA, 1999a; see U.S. EPA 2001b). It does not occur naturally and must be produced industrially for its commercial uses. The main route of occupational exposure to vinyl chloride is by inhalation, which occurs primarily in vinyl chloride/PVC plants and in PVC-processing plants (including packaging, storage and handling of vinyl chloride). There is sufficient evidence that vinyl chloride exposure causes angiosarcoma of the liver and hepatocellular carcinoma. This process is experimental and the keywords may be updated as the learning algorithm improves. From: Systems Biology in Toxicology and Environmental Health, 2015. Vinyl chloride is used primarily to make polyvinyl chloride (PVC); PVC is used to make a variety of plastic products, including pipes, wire and cable coatings, and packaging materials. Instead, it is a manufactured substance produced by breaking down various other substances, gases, and chemicals. 63. The International Agency for Research on Cancer has determined that vinyl chloride is carcinogenic to people, and EPA has determined that vinyl chloride is a human carcinogen. Vinyl chloride in the air breaks down in a few days ... (DHHS) has determined that vinyl chloride is a known carcinogen. Vinyl Chloride, NIOSH Pocket Guide to Chemical Hazards. Vinyl chloride (VC) is a human carcinogen that accumulates in soil and groundwater due to incomplete dechlorination of chlorinated ethenes. Together we can make a difference. This toxic chemical is a known human carcinogen causing liver cancer, brain cancer and some cancers of the blood. The U.S. Occupational Safety & Health Administration provides information about exposure limits to vinyl chloride. Vinyl chloride, the chemical used to make PVC, is a known human carcinogen, according to the World Health Organization’s International Agency for Research on Cancer (IARC). Vinyl chloride is also produced as a combustion product in tobacco smoke. 62. Vinyl chloride is classified by the International Agency for Research on Cancer (IARC) as Group 1, a known human carcinogen. Children products including: water bottles, lunch boxes, toys, small chairs and tables, school bags and stationery items such as pencil boxes can contain some amounts of PVC. In the environment, the highest levels of vinyl chloride are found in air around factories that produce vinyl products. (1) Vinyl chloride was carcinogenic to rats, mice and hamsters when administratered by oral inhalation or i.p. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “Vinyl Chloride was originally published by the National Cancer Institute.”, Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Emotional Support for Young People with Cancer, Young People Facing End-of-Life Care Decisions, Late Effects of Childhood Cancer Treatment, Tech Transfer & Small Business Partnerships, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Step 1: Application Development & Submission, U.S. Department of Health and Human Services. Perform proper exposure measurements so it is known when actions should be taken. 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The Music Performed In Shakespeare's Plays Was Meant To______, Dark Hollow Pond, Swiss Army Knife Uk, How To Know If A Girl Is Serious About You, Falstaff Character Analysis Essay, It Supervisor Jobs, David Denman Parents, Fallout 76 Pets 2020, Paradise Now Living Theatre,

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